TRESK background K + channel deletion selectively uncovers enhanced mechanical and cold sensitivity
نویسندگان
چکیده
منابع مشابه
Modulation of TRESK Background K+ Channel by Membrane Stretch
The two-pore domain K(+) channel TRESK is expressed in dorsal root ganglion and trigeminal sensory neurons where it is a major contributor to background K(+) current. TRESK acts as a break to prevent excessive sensory neuron activation and decreases in its expression or function have been involved in neuronal hyperexcitability after injury/inflammation, migraine or altered sensory perception (t...
متن کاملTubulin Binds to the Cytoplasmic Loop of TRESK Background K+ Channel In Vitro
The cytoplasmic loop between the second and third transmembrane segments is pivotal in the regulation of TRESK (TWIK-related spinal cord K+ channel, K2P18.1, KCNK18). Calcineurin binds to this region and activates the channel by dephosphorylation in response to the calcium signal. Phosphorylation-dependent anchorage of 14-3-3 adaptor protein also modulates TRESK at this location. In the present...
متن کاملFunctional analysis of a migraine-associated TRESK K+ channel mutation.
Recent genetic and functional studies suggest that migraine may result from abnormal activities of ion channels and transporters. A frameshift mutation in the human TWIK-related spinal cord K(+) (TRESK) channel has been identified in migraine with aura patients in a large pedigree. In Xenopus oocytes, mutant TRESK subunits exert a dominant-negative effect on whole-cell TRESK currents. However, ...
متن کاملTRESK Background K+ Channel Is Inhibited by PAR-1/MARK Microtubule Affinity-Regulating Kinases in Xenopus Oocytes
TRESK (TWIK-related spinal cord K(+) channel, KCNK18) is a major background K(+) channel of sensory neurons. Dominant-negative mutation of TRESK is linked to familial migraine. This important two-pore domain K(+) channel is uniquely activated by calcineurin. The calcium/calmodulin-dependent protein phosphatase directly binds to the channel and activates TRESK current several-fold in Xenopus ooc...
متن کاملNon-migraine Associated Tresk K
1 Non-migraine associated TRESK K channel variant C110R does not increase 2 the excitability of trigeminal ganglion neurons 3 4 Authors: 5 Zhaohua Guo, Ping Liu, Fei Ren, and Yu-Qing Cao 6 Affiliation: 7 Washington University Pain Center and Department of Anesthesiology, Washington 8 University School of Medicine, St. Louis, Missouri, USA 9 Running title: 10 TRESK mutation/variant and trigemina...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2020
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp279203